Yes you can and it doesn't matter if you load into a layer ora target clip.
Load up your movie on a layer, then on the next frame or later manipulate the layer using setProperty (_layer1, blah blah) to set the _x and _y.
Position an empty Movie clip on the stage and call it 'target'. Put the center of the clip where you want the center of the loaded clip to be. Then load your movie into y our target clip, 'target'.