Need help redesigning a comic site

Sorry if this is the wrong forum.

Ok, I wanted to my current site:
http://lazylonewolf.comicgenesis.com/

to something like this one:
http://radstylix.deviantart.com/art/...Nine-121424420

I tried using Photoshop's slice tool, but the comic varies in size and some of them are in flash so the tables generated by Photoshop mess it up. The navigation menus(Next,prev..) should follow the size of the comic.

The bottom part contains an iframe for news and stuff and the one beside is is a flash chatbox, 500x300 in size.

Sorry, this is actually my first time in seriously designing a site.
I'll provide more information if anyone's interested, and thank you.