I have recently started working with Mahjong game. But being not so experienced developer. I am just confuse about many aspects of it. So if anyone could throw some light on it. It would be of great help.

I have to build the game where there could be different number of tiles on screen.
32, 48, 64 , 80, 96, 112 and so on

Now I have questions regarding the levels of blocks in this game. I mean the layouts of the game should be predefined or they should be dynamically created? Also I wanted to know how the surface of enable and disable symbols are created?

I am very confused with the math of this game. So any help or suggestions would be appreciated.