Spiderman has many enemies, especially with the green goblin always coming back, so as long as it stays popular there's no doubt that there will be a series of them, like the batman films.

Venom is a very powerful enemy, so it'll probly take a while before they introduce him if they do, which hopefully they will

I'd quite like to see Doc Ock back cos he's always been my fsv baddie. But he's dead...or so it would seem